![]() ![]() Clinical refinement of the automatic lung parameter estimator (ALPE). Thomsen LP, Karbing DS, Smith BW, Murley D, Weinreich UM, Kjærgaard S, Toft E, Thorgaard P, Andreassen S, Rees SE. SpO2 diagram: a non-invasive measure of pulmonary oxygen exchange. The multiple inert gas elimination technique (MIGET). Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs methods. Mortality rates for patients with acute lung injury/ARDS have decreased over time. UK pneumonectomy outcome study (UKPOS): a prospective observational study of pneumonectomy outcome. Powell ES, Pearce AC, Cook D, Davies P, Bishay E, Bowler GM, Gao F, Co-ordinators U. The effects of anesthesia and muscle paralysis on the respiratory system. This is the first work evaluating and demonstrating the feasibility of near real-time VA/Q distribution measurements with the MIGET and the MMIMS methods. MM-S increased significantly after lung injury only in the lavage group, whereas MM-VD increased significantly in both groups. MM-S and MM-VD correlated and agreed well with Riley shunt and with Bohr dead space. MM-VD was on average lower than Bohr dead space (− 0.09 ± 0.14), with lower and upper limits of agreement of − 0.24 and 0.05. ![]() MM-S was on average lower than Riley shunt (− 0.05 ± 0.10), with lower and upper limits of agreement of − 0.15 and 0.04, respectively. We compared MMIMS-derived shunt (MM-S) to Riley shunt, and MMIMS-derived dead space (MM-VD) to Bohr dead space in 349 data pairs. The samples were injected into the MMIMS, and resultant retention and excretion data were translated to VA/Q distributions. Inert gas infusion (saline mixture of SF6, krypton, desflurane, enflurane, diethyl ether, acetone) was maintained, and after induction of lung damage, blood and breath samples were taken at 15-min intervals over 4 h. Thirty anesthetized pigs were randomly assigned to lavage or pulmonary embolism groups. We aimed at comparing shunt fractions and dead space derived from MMIMS–MIGET with Riley shunt and Bohr dead space, respectively. MIGET-when performed using Micropore Membrane Inlet Mass Spectrometry (MMIMS)-has been proven to correlate well with GC-MIGET and reduces analysis time substantially. The multiple inert gas elimination technique (MIGET) using gas chromatography (GC) is an established but time-consuming method of determining ventilation/perfusion (VA/Q) distributions. ![]()
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